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Vascular calcification (VC) is a key process associated with cardiovascular mortality in dialysis patients. Gelsolin is an actin-binding protein that can modulate inflammation, correlated inversely with hemodialysis (HD) mortality and involved in bone calcification homeostasis. In this report, we aim to characterize progression in aortic arch calcification (AAC) and investigate its association with gelsolin.. This randomized, double-blind, active controlled trial was conducted based on Consolidated Standards of Reporting Trials (CONSORT) guidelines [57]. The study was performed in an interventional pain management referral center in the United States, after approval by the Institutional Review Board (IRB) and registration with the U.S. Clinical Trial Registry with an assigned number (NCT01071369). This study was conducted with internal resources of the practice without any external funding, either from industry or elsewhere.. Gingivitis and periodontal changes: inflamed gums appear red and swollen, often bloody. Periodontal disease can lead to gingival recession and dental loss..